Drug Standards
Apexbio Technology LLC LGK-974 1243244-14-5 10mM (in 1mL DMSO)
LGK-974 (CAS 1243244-14-5) is a small molecule inhibitor specifically targeting Porcupine (PORCN) an enzyme essential for the secretion and activity of Wnt proteins LGK-974 inhibits PORCN with an IC50 of approximately 1 nM thus suppressing Wnt signaling pathways as evidenced by dose-dependent reduction in Wnt secretion and downstream AXIN2 expression In cellular assays LGK-974 demonstrated negligible cytotoxicity even at 20 M Animal model studies including MMTV-Wnt1-driven tumors and human head and neck squamous carcinoma (HNSCC) xenografts indicate LGK-974 reduces tumor growth and decreases phosphorylation of LRP6 LGK-974 is thus valuable for investigating PORCN-mediated Wnt signaling and associated cancers
Medchemexpress LLC Naproxen etemesil | 385800-16-8 | 99.9% | 336.40 | 5 MG
Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolyzed to pharmacologically active naproxen once absorbed. Naproxen is a well-known nonsteroidal anti-inflammatory drug, acting as an equipotent inhibitor of COX-1 and COX-2 in intact cells. This compound offers a targeted approach for anti-inflammatory research due to its conversion within the body.
- Inactive prodrug of naproxen
- Hydrolyzed to pharmacologically active naproxen
- Functions as a COX-1 and COX-2 inhibitor
- Demonstrates anti-inflammatory and antifibrotic effects
- Downregulates TGF-β levels
- Inhibits pain, fever, and PGE2
Medchemexpress LLC Meloxicam | 71125-38-7 | 99.9% | 50 MG
Meloxicam (Standard) is the analytical standard of Meloxicam. This product is intended for research and analytical applications. Meloxicam is a non-steroidal antiinflammatory agent that inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively. It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard for Meloxicam
- Intended for research and analytical applications
- Inhibits COX activity
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Naloxone | 465-65-6 | 99.7% | 327.37 | 200 MG
Naloxone is an opioid receptor antagonist that alleviates opioid-overdose-induced respiratory depression. It may cause pulmonary edema and cardiac arrhythmias and is intended for research use only, not for sale to patients.
- Antagonist of opioid receptors
- Alleviates respiratory depression
- Soluble in DMSO (100 mg/mL)
- Stable at 4°C, protected from light, under nitrogen
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Suitable for in vitro and in vivo research applications
- Demonstrates activity in CHO and HEK293 cells
- Effective in animal models, including rats and cats
Sigma Aldrich Fine Chemicals Biosciences Entecavir monohydrate United States Pharmacopeia (USP) Reference Standard | 209216-23-9 | 200MG
Entecavir monohydrate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 295.29 | 209216-23-9 | 200MG
Medchemexpress LLC Loxapine | 1977-10-2 | 327.81 | 100 MG
Loxapine (Standard) is the analytical standard of Loxapine, used for research and analytical applications. It functions as an orally active dopamine inhibitor, 5-HT receptor antagonist, and a dibenzoxazepine anti-psychotic agent. This analytical standard is commonly employed in qualitative, quantitative, and methodological research experiments involving HPLC, GC, and MS.
- Used for research and analytical applications
- Functions as a dopamine inhibitor
- Acts as a 5-HT receptor antagonist
- Used in HPLC, GC, and MS research experiments
Apexbio Technology LLC Diclofenac Sodium 15307-79-6 10mM (in 1mL DMSO)
Diclofenac Sodium (CAS 15307-79-6) is a non-steroidal anti-inflammatory compound that inhibits cyclooxygenase (COX) enzymes It acts as a non-selective COX inhibitor demonstrating IC50 values of 60 nM for ovine COX-1 and 220 nM for COX-2 By suppressing prostaglandin synthesis Diclofenac Sodium exhibits anti-inflammatory antipyretic and analgesic effects It is widely utilized in biomedical research to investigate inflammatory pathways pain mechanisms and the pharmacological modulation of COX activity
Apexbio Technology LLC Capecitabine(Synonyms: Xeloda, Ro 09-1978, N4-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine), 500mg, CAS: 154361-50-9.
Capecitabine (CAS 154361-50-9) chemically defined as N4-pentyloxycarbonyl-5 -deoxy-5-fluorocytidine is an anticancer fluoropyrimidine prodrug that enzymatically converts into the cytotoxic agent 5-fluorouracil (5-FU) through sequential activation by enzymes predominantly expressed in tumors and liver tissues Mechanistically Capecitabine induces apoptosis via Fas-dependent pathways particularly in cells with elevated thymidine phosphorylase (TP) activity as observed in engineered LS174T colon cancer cell lines In mouse xenograft models of colon carcinoma and hepatocellular carcinoma Capecitabine administration reduced tumor growth metastasis and recurrence correlating to PD-ECGF expression These characteristics make Capecitabine relevant in preclinical oncology studies investigating chemotherapy selectivity and tumor-targeted drug delivery
Apexbio Technology LLC Mitotane (Lsodren) 53-19-0 10mM (in 1mL DMSO)
Mitotane (Lysodren CAS 53-19-0) chemically known as o p -DDD is a structural analog of the pesticide DDT with established antiproliferative activity Its primary biological activity involves selective impairment of adrenocortical steroidogenesis resulting in cytotoxicity to adrenal cortical cells Mitotane is utilized predominantly in research protocols exploring therapeutic interventions for adrenocortical carcinoma a malignancy arising from adrenal cortical tissue
eMolecules 20559-55-1 | Medchem Express | Oxibendazole | 50mg | 446272455 | HY-B0299 | MFCD00847838 | 249.27 | C12H15N3O3
ChemScene | 5-Bromo-2-methoxyphenol | 5g | 789369655 | CS-W007658 | 37942-01-1 | MFCD00673137 | 203.035 | C7H7BrO2
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Medchemexpress LLC Metoprolol | 51384-51-1 | 99.99% | 267.36 | 100 MG
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. It exhibits anti-inflammatory, antitumor, and anti-angiogenic properties.
- Orally active.
- Selective β1-adrenoceptor antagonist.
- Shows anti-inflammation, antitumor, and anti-angiogenic properties.
- Cytotoxic effect on U937 and MOLT-4 cells dose and time dependently in vitro.
- Reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice in vivo.
- Shows anti-inflammation and anti-virus effects in a murine model with coxsackievirus B3-induced viral myocarditis in vivo.
- Significantly decreased activated caspase-9 protein expression and inhibits myocardial apoptosis in coronary microembolization (CME) rats in vivo.
Med Vet International Spironolactone 25mg 100 Tablets
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SPIRONOLACTONE 25MG 100 TABLETS
Apexbio Technology LLC Eupatilin 22368-21-4 20mg
Eupatilin (22368-21-4) is a small-molecule agonist targeting peroxisome proliferator-activated receptor alpha (PPAR ) It is designed to modulate PPAR signaling thereby influencing pathways involved in lipid metabolism inflammation suppression and antioxidant response Eupatilin exerts its biological activity primarily through interaction with PPAR receptors modulating downstream signaling cascades associated with inflammation and oxidative stress Based on these pharmacological properties Eupatilin holds research potential in the investigation of inflammatory disorders oxidative damage and metabolic dysregulation